![]() ![]() Both children and adults may experience hoarseness, chronic coughing, or breathing problems. Some children experience some relief or remission of the disease when they begin puberty. Because the tumors grow quickly, young children with the disease may find it difficult to breathe when sleeping, or they may have difficulty swallowing. RRP symptoms tend to be more severe in children than in adults. Eventually, RRP tumors may block the airway passage and cause difficulty breathing. Hoarseness, the most common RRP symptom, is caused when RRP papillomas interfere with the normal vibrations of the vocal folds. Normally, the human voice is produced when air from the lungs is pushed through two side-by-side specialized muscles-called vocal folds-with enough pressure to cause them to vibrate (see illustration). Parts of the respiratory tract affected by RRP Estimates of the incidence for adult-onset RPP range between two to three cases per 100,000 adults in the U.S. Even less is known about the incidence of the adult form of RRP. According to the Centers for Disease Control and Prevention (CDC), estimates of the incidence for juvenile-onset RRP are imprecise but range from two or fewer cases per 100,000 children under age 18. The RRP Foundation estimates that there are roughly 20,000 active cases in the United States. RRP may occur in adults (adult-onset RRP) as well as in infants and small children (juvenile-onset RRP) who may have contracted the virus during childbirth. Although scientists do not fully understand why some people develop the disease and others do not, the virus is thought to be spread through sexual contact or when a mother with genital warts passes the HPV 6 or 11 virus to her baby during childbirth. However, in a small number of people exposed to the HPV 6 or 11 virus, respiratory tract papillomas and genital warts can form. Most people who encounter HPV never develop a related illness. There are more than 150 types of HPV, and they do not all have the same symptoms. RRP is caused by two types of human papilloma virus (HPV): HPV 6 and HPV 11. They often grow back after they have been removed. The papillomas may vary in size and grow very quickly. Although the tumors can grow anywhere in the respiratory tract, they most commonly grow in the larynx (voice box)-a condition called laryngeal papillomatosis. Recurrent respiratory papillomatosis (RRP) is a disease in which benign (noncancerous) tumors called papillomas grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). What is recurrent respiratory papillomatosis? Congressional Testimony and the NIDCD Budget.Research Training in NIDCD Laboratories (Intramural).Types of Research Training Funding Opportunities.About NIDCD's Research Training Program.Scientific Workshop and Meeting Reports.Building a Diverse Scientific Workforce. ![]()
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